Transcriptional regulation of hepatic lipogenesis
نویسندگان
چکیده
منابع مشابه
Regulation of hepatic lipogenesis: the influence of dietary fats.
The factors governing the rate of fatty acid synthesis by the liver have been under investigation in this laboratory. The general study procedure consisted of modifying the nutritional or endocrine state of rats and then measuring the capacity of their excised livers to convert a variety of C4-labeled substrates (glucose, fructose, pyruvate, acetate) to fatty acids. It became clear quite early ...
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Hepatic de novo lipogenesis (DNL) converts carbohydrates into triglycerides and is known to influence systemic lipid homoeostasis. Here, we demonstrate that the zinc finger protein Zbtb20 is required for DNL. Mice lacking Zbtb20 in the liver exhibit hypolipidemia and reduced levels of liver triglycerides, along with impaired hepatic lipogenesis. The expression of genes involved in glycolysis an...
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The hepatic stellate cell (HSC) is now well established as the key cellular element involved in the development of hepatic fibrosis and because of this there is considerable interest in establishing the molecular events that trigger and perpetuate HSC activation. HSC activation at the level of gene transcription requires the coordinated activity of several key transcriptional regulators of the ...
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Hepatic stellate cells (HSC) undergo transdifferentiation (activation) from lipid-storing pericytes to myofibroblastic cells to participate in liver fibrogenesis. Our recent work demonstrates that depletion of peroxisome proliferator-activated receptor gamma (PPARgamma) constitutes one of the key molecular events for HSC activation and that ectopic expression of this nuclear receptor achieves t...
متن کاملRegulation of Lipogenesis
1. A single glucose meal stimulated the incorporation of acetate into fatty acids in liver slices. If the glucose was added in vitro, it had no effect. Fructose and glycerol in vitro markedly stimulated fatty acid synthesis from acetate. Fructose and glycerol probably by-passed a rate-controlling reaction between glucose and triose phosphate. This reaction may have been stimulated by glucose ad...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2015
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm4074